Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems
Identifieur interne : 000700 ( Main/Exploration ); précédent : 000699; suivant : 000701Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems
Auteurs : Osamu Kanauchi [Japon] ; Akira Andoh [Japon] ; Sazaly Abubakar [Malaisie] ; Naoki Yamamoto [Japon]Source :
- Current Pharmaceutical Design [ 1381-6128 ] ; 2018.
Abstract
Recently, the risk of viral infection has dramatically increased owing to changes in human ecology such as global warming and an increased geographical movement of people and goods. Howev-er, the efficacy of vaccines and remedies for infectious diseases is limited by the high mutation rates of viruses, especially, RNA viruses. Here, we comprehensively review the effectiveness of several probiot-ics and paraprobiotics (sterilized probiotics) for the prevention or treatment of virally-induced infectious diseases. We discuss the unique roles of these agents in modulating the cross-talk between commensal bacteria and the mucosal immune system. In addition, we provide an overview of the unique mechanism by which viruses are eliminated through the stimulation of type 1 interferon production by probiotics and paraprobiotics via the activation of dendritic cells. Although further detailed research is necessary in the future, probiotics and/or paraprobiotics are expected to be among the rational adjunctive options for the treatment of various viral diseases.
Url:
DOI: 10.2174/1381612824666180116163411
PubMed: 29345577
PubMed Central: 6006794
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Probiotics and Paraprobiotics in Viral Infection: Clinical Application and Effects on the Innate and Acquired Immune Systems</title><author><name sortKey="Kanauchi, Osamu" sort="Kanauchi, Osamu" uniqKey="Kanauchi O" first="Osamu" last="Kanauchi">Osamu Kanauchi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine,<institution>Shiga University of Medical Science</institution>,<addr-line><city>Otsu</city><postal-code>520-2192</postal-code></addr-line>,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd., 1-13-5, Fukuura, Kanazawa-ku,<addr-line><city>Yokohama</city>,<postal-code>236-0004</postal-code></addr-line>,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andoh, Akira" sort="Andoh, Akira" uniqKey="Andoh A" first="Akira" last="Andoh">Akira Andoh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine,<institution>Shiga University of Medical Science</institution>,<addr-line><city>Otsu</city><postal-code>520-2192</postal-code></addr-line>,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abubakar, Sazaly" sort="Abubakar, Sazaly" uniqKey="Abubakar S" first="Sazaly" last="Abubakar">Sazaly Abubakar</name><affiliation wicri:level="1"><nlm:aff id="aff3">Tropical Infectious Diseases Research and Education Centre (TIDREC), Level 4, Block N & O, Faculty of Medicine,<institution>University of 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Shinjuku-ku,<addr-line><city>Tokyo</city><postal-code>162-8640</postal-code></addr-line>,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku,<addr-line><city>Tokyo</city><postal-code>113-8519</postal-code></addr-line>,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">29345577</idno><idno type="pmc">6006794</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6006794</idno><idno type="RBID">PMC:6006794</idno><idno type="doi">10.2174/1381612824666180116163411</idno><date when="2018">2018</date><idno type="wicri:Area/Pmc/Corpus">000762</idno><idno type="wicri:explorRef" 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Osamu" sort="Kanauchi, Osamu" uniqKey="Kanauchi O" first="Osamu" last="Kanauchi">Osamu Kanauchi</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine,<institution>Shiga University of Medical Science</institution>,<addr-line><city>Otsu</city><postal-code>520-2192</postal-code></addr-line>,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2">Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd., 1-13-5, Fukuura, Kanazawa-ku,<addr-line><city>Yokohama</city>,<postal-code>236-0004</postal-code></addr-line>,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Andoh, Akira" sort="Andoh, Akira" uniqKey="Andoh A" first="Akira" last="Andoh">Akira Andoh</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Medicine,<institution>Shiga University of Medical Science</institution>,<addr-line><city>Otsu</city><postal-code>520-2192</postal-code></addr-line>,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Abubakar, Sazaly" sort="Abubakar, Sazaly" uniqKey="Abubakar S" first="Sazaly" last="Abubakar">Sazaly Abubakar</name><affiliation wicri:level="1"><nlm:aff id="aff3">Tropical Infectious Diseases Research and Education Centre (TIDREC), Level 4, Block N & O, Faculty of Medicine,<institution>University of Malaya</institution>,<addr-line><postal-code>50603</postal-code><city>Kuala Lumpur</city></addr-line>,<country>Malaysia</country>;</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff4">WHO Collaborating Centre for Arbovirus Reference and Research (Dengue/Severe Dengue), Level 4, Block N & O, Faculty of Medicine,<institution>University of Malaya</institution>,<addr-line><postal-code>50603</postal-code><city>Kuala Lumpur</city></addr-line>,<country>Malaysia</country>;</nlm:aff><country xml:lang="fr">Malaisie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><affiliation wicri:level="1"><nlm:aff id="aff5">National Institute of Infectious Diseases, Shinjuku-ku,<addr-line><city>Tokyo</city><postal-code>162-8640</postal-code></addr-line>,<country>Japan</country>;</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff6">Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku,<addr-line><city>Tokyo</city><postal-code>113-8519</postal-code></addr-line>,<country>Japan</country></nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Current Pharmaceutical Design</title><idno type="ISSN">1381-6128</idno><idno type="eISSN">1873-4286</idno><imprint><date when="2018">2018</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Recently, the risk of viral infection has dramatically increased owing to changes in human ecology such as global warming and an increased geographical movement of people and goods. Howev-er, the efficacy of vaccines and remedies for infectious diseases is limited by the high mutation rates of viruses, especially, RNA viruses. Here, we comprehensively review the effectiveness of several probiot-ics and paraprobiotics (sterilized probiotics) for the prevention or treatment of virally-induced infectious diseases. We discuss the unique roles of these agents in modulating the cross-talk between commensal bacteria and the mucosal immune system. In addition, we provide an overview of the unique mechanism by which viruses are eliminated through the stimulation of type 1 interferon production by probiotics and paraprobiotics via the activation of dendritic cells. Although further detailed research is necessary in the future, probiotics and/or paraprobiotics are expected to be among the rational adjunctive options for the treatment of various viral diseases.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alan, H" uniqKey="Alan H">H. Alan</name></author><author><name sortKey="Ian, B" uniqKey="Ian B">B. Ian</name></author><author><name sortKey="Nancy, C" uniqKey="Nancy C">C. Nancy</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Liu, S" uniqKey="Liu S">S. Liu</name></author><author><name sortKey="Chan, T C" uniqKey="Chan T">T.C. Chan</name></author><author><name sortKey="Chu, Y T" uniqKey="Chu Y">Y.T. Chu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="El Sayed, S M" uniqKey="El Sayed S">S.M. El Sayed</name></author><author><name sortKey="Abdelrahman, A A" uniqKey="Abdelrahman A">A.A. 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Meriluoto</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Japon</li><li>Malaisie</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Kanauchi, Osamu" sort="Kanauchi, Osamu" uniqKey="Kanauchi O" first="Osamu" last="Kanauchi">Osamu Kanauchi</name></noRegion><name sortKey="Andoh, Akira" sort="Andoh, Akira" uniqKey="Andoh A" first="Akira" last="Andoh">Akira Andoh</name><name sortKey="Kanauchi, Osamu" sort="Kanauchi, Osamu" uniqKey="Kanauchi O" first="Osamu" last="Kanauchi">Osamu Kanauchi</name><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name><name sortKey="Yamamoto, Naoki" sort="Yamamoto, Naoki" uniqKey="Yamamoto N" first="Naoki" last="Yamamoto">Naoki Yamamoto</name></country><country name="Malaisie"><noRegion><name sortKey="Abubakar, Sazaly" sort="Abubakar, Sazaly" uniqKey="Abubakar S" first="Sazaly" last="Abubakar">Sazaly Abubakar</name></noRegion><name sortKey="Abubakar, Sazaly" sort="Abubakar, Sazaly" uniqKey="Abubakar S" first="Sazaly" last="Abubakar">Sazaly Abubakar</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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